imageASPR.Science

Quantum effects in biological systems

A unique original study on quantum consciousness, Orch-OR theory, and neuronal microtubules

00:00

Most of us experience ourselves as a whole, continuous personality, through subjective experience. But where does this feeling come from? What makes us us? I went online with this question. Perhaps the answer lies deeper not only in synapses and neural networks, but also in quantum mechanisms. Interesting. There is a working hypothesis that consciousness is at least partly based on cognitive processes that are quantum in nature. Today we will try to figure this out. This orgor theory was proposed by physicist Roger Penrose and neuroanesthesiologist Stuart Hammeroff

00:45

According to their model, subjective experience arises from quantum processes occurring in microtubules, dense cylindrical structures inside neurons, about 25 nm in diameter, made of the protein tubulin. In addition to the structural and transport functions, in this model microtubules can act as sub-iron quantum computing systems. Logical, isn't it? Tubulin is thought to exist in two conformational states that exist in superposition. Functional analogue of qubits. If many such molecules interact coherently, a quantum computing process occurs.

02:10

According to Penrose's model, this process ends with objective reduction, the spontaneous collapse of the superposition. When the system reaches a certain gravitational threshold, it is this moment that is interpreted as an elementary act of consciousness. Although Orch-OR is not a mainstream theory in neuroscience, evidence has emerged in recent years to support its physical validity. But where is the evidence?

03:30

In 2023, it was discovered that tubulins within microtubules exhibit the effect of superradiation, a cooperative radiation caused by the coherent interaction of many molecules. This is precisely what testifies to the possibility of the existence of coherent states inside microtubules, a key condition for quantum computing. And yet, scientists regularly make new assumptions. For example, in 2024, a paper was published showing that neurons are capable of emitting entangled photons, a phenomenon previously thought impossible in biological conditions.

04:45

Can't be. This discovery shows and indicates that states of quantum entanglement can be maintained in the brain. There is a strange feature. The brain is too hot, humid and noisy an environment for stable quantum states, but it is possible. Moreover, it is not uncommon. After all, quantum biology has already shown the opposite. Similar effects are observed in plant photosynthesis and magnetoreception in birds, where biology can adjust physics to its own purposes.

05:40

Additional support for the quantum model of consciousness is offered by the theory of physicist Matthew Fisher. He proposed that the nuclear spins of phosphorus involved in phosphate groups could remain coherent for seconds. Posner molecules, phosphate clusters capable of protecting these states from decoherence, are considered as possible quantum registers built into neuronal metabolism. We'll turn to research on the effects of anesthetics, but I certainly didn't expect this. Xenon isotopes with non-zero nuclear spin have been shown to have lower anesthetic activity than isotopes without spin, despite identical chemical properties.

06:30

This difference is not explainable from the standpoint of classical biochemistry, but indicates the possible involvement of quantum spin effects in the generation of consciousness. It can be assumed that anesthesia suppresses the coherent quantum states involved in its formation. In addition, a meta-analysis of studies on the effects of noble gases, including xenon, has shown their proven effects on neuroprotective functions: neurotransmitters, membrane complexes and transcription factors. Coincidence? Don't think. These data confirm that xenon actively influences all levels associated with the functioning of consciousness. After all, even without direct evidence of quantum computing in the brain, we have a solid biological basis for a deep connection between anesthesia and fundamental processes of subjective experience. In 2025, this work showed that the neuron excitation equation, including the classical Hodgkin-Huxley model, allows for quantum formalization. This creates a potential mathematical basis for describing neural activity as a quantum process. A strong statement. I will check it, of course. All these data are not direct proof of the Orch-OR theory, but they confirm its physical feasibility. Consciousness probably arises from the interaction of different levels from the classical neural network to quantum information processes. The quantum component is not necessarily dominant, but perhaps fundamentally necessary. It can be realized through microtubules, nuclear phosphorus spins, photon channels. In those biological structures where quantum superpositions, coherence and non-local interactions are allowed. This approach does not deny classical models, but complements them, revealing the deep physical layer of subjective experience. In the long term, this interpretation could influence not only the philosophy of consciousness, but also the development of cognitive interfaces, quantum neuroprosthetics, and perhaps the reconsideration of the very boundary between biological intelligence and artificial intelligence. Those who don't understand will understand. And remember, trust is better than questions.

Video Timeline

Key references

#11989

The Emperor's New Mind: Concerning Computers, Minds, and the Laws of Physics

Авторы: R. Penrose

Журнал: Oxford University Press ,

CrossrefPubMedWeb of ScienceGoogle Scholar
#21994

Shadows of the Mind: A Search for the Missing Science of Consciousness

Авторы: R. Penrose

Журнал: Oxford University Press ,

CrossrefPubMedWeb of ScienceGoogle Scholar
#31996

Orchestrated reduction of quantum coherence in brain microtubules: A model for consciousness

Авторы: S. R. Hameroff, R. Penrose

Журнал: Mathematics and Computers in Simulation 40, 453–480

CrossrefPubMedWeb of ScienceGoogle Scholar
#42014

Consciousness in the universe: A review of the 'Orch OR' theory

Авторы: S. Hameroff, R. Penrose

Журнал: Physics of Life Reviews 11, 39–78

CrossrefPubMedWeb of ScienceGoogle Scholar
#51987

Ultimate Computing: Biomolecular Consciousness and Nanotechnology

Авторы: S. Hameroff

Журнал: North-Holland ,

CrossrefPubMedWeb of ScienceGoogle Scholar
#62014

The feasibility of coherent energy transfer in microtubules

Авторы: T. J. A. Craddock, D. Friesen, J. Mane, S. Hameroff, J. A. Tuszynski

Журнал: Journal of the Royal Society Interface 11, 20140677

CrossrefPubMedWeb of ScienceGoogle Scholar
#72016

Superradiance in biological systems: The case of microtubules

Авторы: G. L. Celardo, P. Giorda

Журнал: Physical Review E 94, 032413

CrossrefPubMedWeb of ScienceGoogle Scholar
#82015

Quantum information processing in the brain: An Orch OR perspective

Авторы: D. D. Georgiev

Журнал: NeuroQuantology 13, 174–187

CrossrefPubMedWeb of ScienceGoogle Scholar
#92020

Quantum entanglement in biological systems: A review

Авторы: S. Kumar, S. Ghosh

Журнал: Quantum Information Processing 19, 343

CrossrefPubMedWeb of ScienceGoogle Scholar
#101998

Quantum computation in brain microtubules? The Penrose-Hameroff 'Orch OR' model of consciousness

Авторы: S. Hameroff

Журнал: Philosophical Transactions of the Royal Society A 356, 1869–1896

CrossrefPubMedWeb of ScienceGoogle Scholar
#112000

Importance of quantum decoherence in brain processes

Авторы: M. Tegmark

Журнал: Physical Review E 61, 4194–4206

CrossrefPubMedWeb of ScienceGoogle Scholar
#122001

My Double Unveiled: The Dissipative Quantum Model of Brain

Авторы: G. Vitiello

Журнал: John Benjamins Publishing ,

CrossrefPubMedWeb of ScienceGoogle Scholar
#131967

Brain physics and many-body problems

Авторы: L. M. Ricciardi, H. Umezawa

Журнал: Kybernetik 4, 44–48

CrossrefPubMedWeb of ScienceGoogle Scholar